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multitude who undergo common routine , such as CT CAT scan and angiogram , may be at greater danger for thyroid problems , harmonise to a recent study .
The subject found that people who received intravenous iodinated line medium , which helps doctors see blood vessel and organs during imaging procedures , had a higher chance of developing thyrotoxicosis than those who did not .
CT scans of a human brain.
" We were surprised at how strong it was . masses had twice the likelihood of develop hyperthyroidism when they received iodinated contrast medium , " said study researcher Dr. Steven Brunelli , an epidemiologist at Brigham and Women ’s Hospital and assistant prof at Harvard Medical School .
Hyperthyroidism happen when the thyroid gland produces too much thyroid gland endocrine . Symptoms let in weight loss , affectionateness trembling , oestrus sensitiveness and fatigue , but many case are symptomless . However , people without symptoms may still confront an increased peril of cardiovascular disease .
The finding need to be confirm , and people should not relinquish procedure based on this work , Brunelli said .
Rather , research worker should attempt to try out the grounds for the link , he say .
The determination are detailed today ( Jan. 23 ) in the daybook Archives of Internal Medicine .
thyroid gland trouble
In 2003 , about 80 million doses of ICM were administered by vein , and the act has arise in late years , Brunelli pronounce . Previous discipline found that a relationship live between ICM and kidney legal injury , but none had examined in depth the relationship between ICM and thyroid gland disorderliness .
Brunelli and his confrere prove data from more than 4.5 million patientsat Brigham and Women ’s Hospital and Massachusetts General Hospital over the course of 20 yr . They selected hoi polloi who had double been tested for thyrotrophin , a thyroid gland - shake up hormone , over a two - workweek to two - yr full stop . Thyrotropin levels make up one’s mind whether or not someone has a thyroid disorder .
All bailiwick participant had normal thyroid gland mapping at first testing , and the restraint group , consisting of 3,678 people , had normal thyroid gland function upon second testing . However , 191 people had develop hyperthyroidism , and 227 people had developed hypothyroidism , upon 2d testing .
Symptoms of hypothyroidism , which pass off when the thyroid gland does not bring forth enough thyroid gland hormone , include free weight gain , sensitivity to coldness and languor .
The multitude with unnatural thyroid gland part were equalize with control based on raceway , sexuality , age and other factors . After taking into account everyone ’s pic to ICM , the researchers observe that ICM was powerfully consociate with the development of hyperthyroidism .
A petty analysis of the information evince a family relationship between ICM and cases dangerous of hypothyroidism and hyperthyroidism .
The study only examined the effect of ICM administered through veins . It did not probe the personal effects of crapulence ICM , as is done for some CT scans , or the force of get I - devoid contrasts , like those used for MRIs .
Skip the scan ?
Dr. Elizabeth Pearce , assistant professor of music and Boston University School of Medicine who take thyroid problems , called the data " novel . "
" One of most interesting finding is that hyperthyroidism occurred more frequently in masses who did n’t have underlying thyroid problems , " she said . " We have sex for foresightful meter some mass were at higher risk of infection for thyrotoxicosis , like people with iodine deficiency who finally get exposed to tincture of iodine . "
Pearce say this study point that there is a bragging challenge in determining who is at risk for thyroid abnormality . Typically , thyroid freakishness are associated with let a goiter , an enlarged thyroid , or thyroid gland nodule , which can be felt in the neck opening .
Pearce recommended that if someone knows they are at gamy risk for thyroid dysfunction due to known history , they should experience for a struma before receiving ICM or have their thyroid gland function monitored after an imaging subroutine .
Brunelli said that in life or death berth , such as an acute coronary or a late Cancer the Crab diagnosing , " the patient role should not view encroachment of ICM on thyroid disease . "
" There are bigger fish to fry , " he tell . " the great unwashed should not over - interpret these finding and foreswear a procedure . "
Brunelli cautioned that before this study can be amply translate , the data postulate to be formalize in other groups of patient . "
He articulate the next level of studies will attempt to figure out the risk of ICM on the thyroid versus the welfare of the imaging operation .
The study was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases , National Institute of Health .
slip by it on : Such vernacular procedures as CT scans may cause thyroid gland problems .
